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Furthermore, the half-life of pure Testosterone is approximately 6 ‘ 12 hours, which necessitated either daily or multiple times per day injections. It was not long afterwards during the 1930s that it was discovered that different carboxylic acids could be bonded (via ester bonding) onto the 17-beta hydroxyl group of the steroid structure, which would extend the half-life and release rate of the hormone. The shorter the ester bond, the shorter the half-life is granted to the hormone. The longer the ester bond, the longer the half-life. One of the first esterified formats of Testosterone (also known as a Testosterone ester) was Testosterone Propionate, a fast acting variant that exhibits a half-life of 4. Although this was much longer than pure Testosterone’s half-life, it was still not very practical for medical use. Testosterone Propionate, however, has gained much popularity among athletes and bodybuilders due to the fact that because it is a fast acting variant of Testosterone, blood plasma levels build up in the body quite quickly, resulting in a quicker onset of physique and performance changes and effects. Schering AG was the first company to market and release Testosterone Propionate onto the prescription market. It is still in wide use today by bodybuilders and athletes, though it is the least popular variant. There also exists Testosterone Enanthate and Testosterone Cypionate, two long-acting Testosterone esters that each possess half-lives of 7 ‘ 10 days and 10 ‘ 12 days respectively. The two are almost considered the exact same due to the very similar half-lives. Testosterone Enanthate is of European/international origin (originally manufactured as Testoviron by Schering), while Testosterone Cypionate is of American origin (originally manufactured as Depo-Testosterone by Upjohn). There were also developments of products which contained blends of different Testosterone esters, such as Sustanon 250 and Omnadren. The availability of different types of Testosterone products for athletes and bodybuilders is very extensive. Contrary to what might be commonly touted in internet message boards, forums, and common chatter among anabolic steroid users in gyms, the ester that is affixed to Testosterone (or any anabolic steroid for that matter) serves only to augment the release rate and half-life of the hormone. Esterification does nothing to alter the pharmacology of the hormone itself within the human body. In order for that to occur, direct modifications to the integral parts of the chemical structure itself must occur, which would result in Testosterone becoming a new anabolic steroid ‘ it would no longer be Testosterone any more. Testosterone, as previously mentioned, is available in a plethora of different forms and product types on the black market. 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